An examination of the relationship between coral calcium hydride and hormone secretion.

Examination of the relationship between coral calcium hydride and hormone secretion.

Subjects were made up of:
5 male athletes (average age 37)
11 female athletes (average age 23)

Subjects consumed 1 capsule of coral calcium hydride per day as a base and 2 capsules before exercise. The participants exercised for one hour. Changes in hormone secretion were examined by blood tests, which covered 15 different items and were administered before and after exercise. We compared results after the 4th and 12th week.

1) Estradiol (E2): There was a significant rise in female subjects in the 4th and 12th week.
2) Adrenocorticotropic hormone (ATCH): Overall there was a decline of this hormone in male participants but a significant rise in female subjects in the 4th and 12th week.
3) Catecholamines: Adrenaline rose significantly in male subjects in the 4th week. In female subjects adrenaline rose significantly in the 4th and 12th weeks. Noradrenalin rose significantly in female subjects in the 12th week.

The stress hormone and sex hormone reactions, especially with female subjects, may be the result of coral calcium hydride’s effect on ATP production.

The physical property of water is changed by metal hydride and achieves stable hydrogen saturation.

Awareness of the antioxidant function of hydrogen has grown recently. However, it is difficult to store hydrogen in water stably. We examined the question of hydrogen stability in water.

We combined ordinary tap water with the coral calcium metal hydride substance. We then infused hydrogen gas into the water until saturation. OPR and pH were then measured chronologically against the level of dissolved hydrogen.

After 12 hours the amount of dissolved hydrogen gas in normal water had dissipated to zero. However, in water containing metal hydride, it took 20 hours for the dissolved hydrogen to reach zero and then after 84 hours hydrogen again started to be emitted. This hydrogen emission continued for over a week.

The physical property of water changes when metal hydride is placed into it. Alkaline reduction ionic mineral water is produced, which is close to oxygen-free. It is theorized that hydrogen effectively enters a plasma state, which enables hydrogen to be stabilized within the water.

The effects of coral calcium hydride on human hyperlipemia

We examined the effects of orally ingestible coral calcium hydride (referred to as CCH) on human hyperlipemia.

After providing dietary guidance to 10 adult male and female patients with hyperlipemia, we took fasting blood samples at 2 and 4month intervals. The subjects then began taking 1,500 to 2,000mg per day of the hydrogen emitting CCH supplements, divided into twice-daily doses. Fasting blood samples were then taken at 2 and 4month intervals.

Two months after dietary guidance, neutral lipids went down significantly from 244 ± 19mg/dL to 188 ± 14mg/dL. In the following 2 months, subjects were unable to reach normal lipid levels and no further reductions were realized. Two months after starting on CCH supplements, subjects’ lipid levels fell significantly to 141 ± 12mg/dL and stabilized within the normal range. No significant changes were noted in the levels of HDL, LDL or total cholesterol with respect to dietary guidance or the CCH substance. However, weight was reduced significantly with subjects losing, on average, 1.3kgs following diet guidance and a further 2.1kgs, on average, after taking the CCH supplements. Additionally, subjects with diabetes were all confirmed to have reduced levels of A1c.

CCH, developed by Dr. Taneaki Oikawa, consists of edible coral calcium and is processed to form a metal hydride. In our experiments, the CCH substance significantly lowered the level of neutral lipids and lowered weight. Subjects with diabetes experienced an improvement in their blood sugar level (A1c), which may suggest the effects of CCH influenced improvements in cellular energy metabolism. CCH holds future potential as a useful adjunct to antioxidant therapy and in supporting measures to improve metabolism. This summary was presented at the 106 th Annual Meeting of the Japan Internal Medicine Society (2009).

The impact of coral calcium hydride on gene expression and the functional networks of senescence-accelerated mice.

The use of senescence-accelerated mice /P-8 (SAM/P-8) is well known. Scientific understandings of premature aging point to a breakdown in the balance between oxidation and reduction. We administered the substance known as coral calcium hydride (CCH) to mice and looked for an antioxidant activity that may affect gene expression in the hippocampus.

We administered CCH to SAM/P-8 for 10 weeks and analyzed the gene expression of the mice using a DNA microarray method.

Result and conclusion
Two kinds of gene expression patterns were observed. One was the gene group related to glycolipid metabolism, which had a prominent rise in expression. The other was the gene group related to carcinogenesis and immunity, which showed a decline in expression.

 “Reactive Oxygen Species, Nitric Oxide, Antioxidants and Human Health.”

National Scientific-Practical Conference with International Participation
(Sep 14-18, 2009, Smolensk, Russia)
Midori Hiramatsu1, Kotoe Takahashi*1, Taneaki Oikawa*2, Kazuo Nakamoto*2, Fusako Takayama*3, Motoo Nakajima*4, Kazumasa Aoyagi*4, and Ichiro Sasahara*5
*1. The Tohoku University of Community Service and Science, *2. The Institute for Creative Biotechnology Co., Ltd. *3. Dept.of Anti-Aging Food Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences *4. The Tsukuba University of Technology, Center for Integrative Medicine, *5. Li.Co STUDY Pro, Japan

Dr. Hiramatsu presented the results of free radical experiments on male SAMP8, SAMR1, and ddY mice fed the hydrogen emitting substance, coral calcium hydride (CCH). The experiments and results were as follows:(a)Electron spin resonance (ESR) measurements on the top liquid of centrifuged CCH solution.
(b)Fourteen-week-old male SAMP8 and SAMR1 mice were fed solid food containing 0.1% CCH for 1 month and the levels of malondialdehyde formation in the brain were measured.

Eight-week-old male ddY mice have had 7.2mg/40g body weight/day of CCH supernatant administered 3 times a day and malondialdehyde formation measured. Three-month-old male ddY mice were fed solid food containing 0.1% CCH for 3 months. Carbonyl protein and 8-Hydroxy-2-deoxyguanosine (8-OHdG) were assayed.

(a)CCH solution very effectively eradicated the 1,1-diphenyl-2-picrylhydrazyl (DDPH) radical and showed a slight reduction of the hydroxyl radical.
(b) CCH inhibited, 1) lipid peroxide formations in the brain homogenate and 2) oxidization of DNA within blood plasma of ddY mice.

Experimental results suggest CCH may be effective in the delay of aging and the prevention of lifestyle-related diseases

Effects of the new antioxidant, Dr. ZP-O AHR, on the cytotoxicity of immortalized hepatocytes induced by p-dichlorobenzene.

Japan Society for environmental chemistry
International session in the 17th symposium in Kobe
Presented at the 49th Annual Meeting of The Japanese Society of Plant Physiologists, Sapporo, March 20-22, 2008

Observations on the effect to cut flowers by alkaline reduction water produced using magnetic bipolar bisque fired ceramic balls (with a 20mV difference between the magnetic poles)

The Institute for Creative Biotechnology, Ltd
Taneaki Oikawa And Hiroe Watanabe

It has been posited that hydrogen plasma (H2⇔H⁺+H⁻) can be induced under a high heat, oxygen-free, reduction environment. Our laboratory has undertaken a 10-year study to examine the potential of inducing a plasma reaction in water using magnetic bipolar bisque fired ceramic balls.

Our studies on the physicochemical properties of the ceramic balls found that when the balls are exposed to water they release hydrogen gas, with the surrounding water generating a level of about pH10 and ORP at ?250mV. Tests have found that vast amounts of hydrogen gas can be dissolved in water in this condition. We have made observations of how the phenomenon described affects plants. Experiments have demonstrated the ability to maintain the condition of cut flowers for over 6 months. We are now able to describe some fascinating effects not previously reported in other studies. →pdf file

Effect of minus hydrogen ion food 「Dr.ZP-O AH®」on malondialdehyde formation in the brain of senescence accelerated mice (SAMP8) and ddY mice

The 34th Conference of the Japan Brain Science Society
Venue: Izumo Shrine Training Institute

The 22nd Annual Meeting of the Council for SAM Research
Venue: Tohoku Community Service and Science University, Sakata City Community Service Training Center Multipurpose Hall

Midori Hiramatsu1, Tomoko Takahashi *1, Taneaki Oikawa *2
*1. Graduate School, the Tohoku University of Community Service and Science
*2. The Institute for Creative Biotechnology

【Abstract】Negative hydrogen ion food 「Dr.ZP-O AH®」is a fine coral powder gotten after oxidation burning at 700°C for four hours and reduction burning at 650° in a mixed atmosphere with the ratio of H2:N2=1:9 for four hours. We examined the antioxidant action of 「Dr.ZP-O AH®」on free radical scavenging activity and malondialdehyde formation in the brain of SAMP8 and ddY mice. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical was analyzed by an electron spin resonance spectrometer. Pellets containing 0.1% 「Dr.ZP-O AH® was orally administered to 3 months old of SAMP8 and SAMR1 for one month. As for ddY mice, 7.2mg/40g/day of 「Dr.ZP-O AH®」was forcibly administered to stomach three times a day for 7 days. Formed malondialdehyde by ferrous sulfate and ascorbic acid in the brain homogenate was analyzed using BIOXYTECH® LPO-586. 「Dr.ZP-O AH®」was found to have free radical scavenging activity and orally administered SAMP8 by 「Dr.ZP-O AH®」showed fine fair and high movement compared to that of SAMP8, which has not been administered. Oral administration of 「Dr.ZP-O AH®」 decreased malonaldehyde formation in the brain homogenate of ddY mice. However, no effect was found in the brain of SAMP8 and SAMR1. These results suggest that 「Dr.ZP-O AH®」might affect the brain of SAMP8 and ddY mice.